| Abstrakt: |
The efficacy of growth hormone (GH) therapy was evaluated in patients with chronic fatigue syndrome (CFS)who had peak serum GH levels below 10 @mg/I during stage-controlled sleep. Twenty patients (7 men, 13 women; age range, 30-60 years) with CFS were randomized to receive placebo or GH therapy, 6.7 @mg/kg/day (0.02 IU/kg/day), for 12 weeks. Following this double-blind treatment period, the 17 patients remaining in the study were given GH therapy at the above dose for an open period of 9 months. Mean (+/- SD) serum levels of insulin-like growth factor I (IGF-I) increased during GH treatment, from 173 +/- 46 @mg/I to 296 +/- 89 @mg/I (P < 0.001); IGF-I SDS values increased from -0.45 +/- 1.14 to +/-1.43 +/- 1.09 (P < 0.001). Fat-free mass and total body water were significantly increased after 12 months of treatment. Although quality of life, as assessed using two different questionnaires, did not improve significantly during GH treatment, four patients were able to resume work after a long period of sick leave. |
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