| Autor: |
Pinnix, Inga, Ghiso, Jorge A., Pappolla, Miguel A., Sambamurti, Kumar |
| Zdroj: |
American Journal of Geriatric Psychiatry; May2013, Vol. 21 Issue 5, p474-483, 10p |
| Abstrakt: |
The article looks at the creation of carboxyl terminal (C-terminal) fragments of the Alzheimer amyloid β-protein precursor (APP) by cleavage by the γ-secretase enzyme, with particular focus on amino acid lengths of C-terminal fragments related to familial Alzheimer's disease (FAD) genetic mutations of APP and presenilin 1 protein. It is suggested that FAD mutations inhibit the cleavage activity of γ-secretase and promote the pathogenesis of Alzheimer's disease. |
| Databáze: |
Supplemental Index |
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