| Autor: |
Safari, Hamid R., Alsulyman, Owaidah M., Gherman, Robert B., Goodwin, T. Murphy, Safari, H R, Alsulyman, O M, Gherman, R B, Goodwin, T M |
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| Zdroj: |
American Journal of Obstetrics & Gynecology; May98, Vol. 178 Issue 5, p1054-1058, 5p |
| Abstrakt: |
Objective: Our purpose was to describe the effect of oral methylprednisolone on the course of refractory hyperemesis gravidarum.Study Design: Patients with intractable hyperemesis gravidarum were candidates for oral methylprednisolone. Forty-eight milligrams per day was given for 3 days followed by a tapering dose over 2 weeks. If vomiting recurred after 2 weeks of therapy or during tapering, the medication was restarted or extended but not longer than 1 month total.Results: Seventeen of 18 patients (94%) were free of vomiting and were able to tolerate a regular diet within 3 days. Seven did not have further symptoms during their pregnancies. Nine vomited during or after tapering, but 7 of these responded to extension or reinstitution of therapy. Four of 6 patients on total parenteral nutrition at the start of therapy had a complete response within 3 days.Conclusions: A short course of oral methylprednisolone appears to be a reasonable therapeutic alternative for intractable hyperemesis. [ABSTRACT FROM AUTHOR] |
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