| Autor: |
Mochizuki, Seibu, Takeda, Nobuakira, Nagano, Makoto, Dhalla, Naranjan S., Tani, Masato, Shinmura, Ken, Hasegawa, Hiroshi, Suganuma, Yukako, Hayashi, Yoko |
| Zdroj: |
Ischemic Heart; 1998, p461-471, 11p |
| Abstrakt: |
Some animal studies indicate that ischemic tolerance is decreased in the senescent myocardium. However, the results of cardiac operations in the elderly are compatible with those performed in middle-aged people. It is important to determine whether ischemic tolerance may be decreased in middle age. Hearts from young adult (12 weeks old) or the middle-aged (50 weeks old) Fischer 344 rats were subjected to 15, 20, or 25 minutes of global ischemia followed by reperfusion. The recovery of left ventricular function and high-energy phosphates was significantly lower in the hearts of middle-aged rats than in those of the young adult rats after any period of global ischemia. The increase in left ventricular end-diastolic pressure was also greater in the middle-aged rats, although there were no diferences in these indexes in the two age groups before the induction of ischemia. The incidence of reperfusion-induced ventricular fibrillation was significantly higher and the release of creatine kinase in the coronary effluent during reperfusion significantly greater in the middle-aged rats than in the young adult rats. Results indicate that rat hearts are more vulnerable to ischemia, even in middle age. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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