| Autor: |
Bürkle, Alexander, Schreiber, Valérie, Ricoul, Michelle, Amé, Jean-Christophe, Dantzer, Françoise, Meder, Véronique, Spenlehauer, Catherine, Stiegler, Patrick, Niedergang, Claude, Sabatier, Laure, Favaudon, Vincent, Ménissier-de Murcia, Josiane, de Murcia, Gilbert |
| Zdroj: |
Poly(ADP-Ribosyl)ation; 2006, p13-31, 19p |
| Abstrakt: |
Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity is immediately stimulated by DNA strand-breaks. This review summarizes our present knowledge of the structure and function of PARP-2, the closest relative to PARP-1. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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