| Autor: |
Harris, J. R., Biswas, B. B., Quinn, P., Kundu, Tapas K., Bittman, R., Dasgupta, D., Engelhardt, H., Flohe, L., Herrmann, H., Holzenburg, A., Nasheuer, H-P., Rottem, S., Wyss, M., Zwickl, P., Wacker, David A., Frizzell, Kristine M., Zhang, Tong, Kraus, W. Lee |
| Zdroj: |
Chromatin & Disease; 2007, p45-72, 28p |
| Abstrakt: |
Poly(ADP-Ribose) Polymerase-1 (PARP-1) is the prototypical and most abundantly expressed member of a family of PARPs that catalyze the polymerization of ADP-ribose (ADPR) units from donor NAD+ molecules on target proteins. PARP-1 plays roles in a variety of genomic processes, including the regulation of chromatin structure and transcription in response to specific cellular signals. PARP-1 also plays important roles in many stress-induced disease states. In this chapter, we review the molecular and cellular aspects of PARP-1's chromatin-modulating activities, as well as the impact that these chromatin-modulating activities have on the regulation of gene expression. In addition, we highlight the potential therapeutic use of drugs that target PARP-1's enzymatic activity for the treatment of human diseases [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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