| Autor: |
Biswas, B. B., Quinn, P., Flohé, Leopold, Harris, J. Robin, Ishii, Tetsuro, Yanagawa, Toru |
| Zdroj: |
Peroxiredoxin Systems; 2007, p375-384, 10p |
| Abstrakt: |
Some members of the Prx family are up-regulated in cells under stress conditions. Prx I is the major cytoplasmic Prx and is known as a stress-inducible antioxidant enzyme. Various stress agents or conditions activate Prx I gene expression in vitro and in vivo. The transcription factor Nrf2 and its inhibitor Keap1 play an essential role in the regulation of the stress-induced Prx I gene activation through the ARE/EpRE (antioxidant/electrophile response element). The expression levels of Prx II and III are also up-regulated under stress conditions, although the molecular mechanisms of their up-regulation have not yet been thoroughly studied. Gene expression of both Prx I and II is activated by X-ray irradiation of the testis. Mitochondrial Prx III is up-regulated by stress agents in both cultured cells and experimental animals. The up-regulation of the Prxs in cells and tissues under oxidative stress conditions is one of the cellular recovery responses after oxidative damage [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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