| Autor: |
Aguayo, Albert, Ascher, Philippe, Berthoz, Alain, Besson, Jean-Marie, Bizzi, Emilia, Bjorklund, Anders, Bloom, Floyd, Bockaert, Joël, Buser, Pierre, Changeux, Jean-Pierre, Cotman, Carl, Dunnett, Steven, Fink, George, Gage, Fred, Glowinski, Jacques, Kordon, Claude, Lacour, Michel, Moal, Michel, Lynch, Gary, Milner, Brenda |
| Zdroj: |
Memories: Molecules & Circuits; 2007, p83-98, 16p |
| Abstrakt: |
The persistence of memories reflects a dynamic, rather than a stable, process. The reactivation of a previously learned memory, for example by re-exposure to a conditioned stimulus, renders it labile, such that the concomitant administration of a variety of amnestic agents results in a reduced ability subsequently to retrieve that memory. This reactivation-dependent amnesia suggests that memoriesmay undergo cycles of reactivation followed by a process of what has been called "reconsolidation". This review will discuss several of the central features of memory reconsolidation, taking a translational view of the potential of disrupting reconsolidation as a treatment strategy for maladaptive memory disorders such as post-traumatic stress and drug addiction. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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