Gastroprotective effects of honey and glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat.

Autor: Gharzouli, Kamel, Amira, Smain, Gharzouli, Akila, Khennouf, Seddik
Předmět:
Zdroj: Experimental & Toxicologic Pathology; Sep2002, Vol. 54 Issue 3, p217-221, 5p
Abstrakt: Summary: The gastric cytoprotective properties of natural honey (monofloral and polyfloral specimens) and of a glucose-fructose-sucrose-maltose mixture (gfsm) was evaluated in the rat using absolute ethanol, indomethacin and acidified acetylsalicylic acid (asa-hcl) as necrotising agents. Prior gastric administration of honey (2.5 g/kg) to animals induced a net reduction of hemorrhagic lesions length of the mucosa. Protection of the stomach elicited by both types of honey and gfsm was almost total against ethanol-induced lesions. Similar results were also observed when using asa-hcl except that the percent protection was 87%. The percent reduction of indomethacin-induced gastric lesions was variable according to the nature of the test solution: gfsm mixture (41.1%) < polyfloral honey (55.2%) < monofloral honey (64.0%). Perfusion of the stomach with isotonic honey resulted in (1) a 70% reduction of the area of the lesions caused by ethanol, (2) the failure to prevent the transmural potential difference fall induced by ethanol, (3) an increase of basal and histamine-stimulated acid secretion. These results suggest that sugar rich solutions (gfsm and honey) may prevent gastric damage by a mechanism involving the release of some protective agents. [Copyright &y& Elsevier]
Databáze: Supplemental Index
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