| Autor: |
XIAO, Longgao, ZHAO, Yueqin, DING, Xiao, LIU, Hui, ZHU, Guangyu, LI, Yanxi, YAN, Huan, FANG, Xin, ZHAO, Yuhan, LIU, Haiyang |
| Zdroj: |
Chinese Journal of Natural Medicines; Nov2024, Vol. 22 Issue 11, p1011-1019, 9p |
| Abstrakt: |
Three novel sesquiterpenoid heterodimers, designated as auckcostusolides A–C (1 – 3), were isolated from Aucklandia costus leaves. The structures of compounds 1 – 3 were elucidated through comprehensive spectroscopic analysis, with their absolute configurations established using a combination of X-ray single-crystal diffraction and electronic circular dichroism (ECD) calculations. Notably, compounds 1 and 2 , despite sharing identical planar structures derived from two identical sesquiterpenoids, exhibited opposite configurations at C-11 and C-8′. This configurational difference can be attributed to distinct Diels−Alder cycloaddition processes between the sesquiterpenoid monomers. Additionally, the cytotoxic effects of compounds 1 – 3 were evaluated against colorectal cancer HCT116 cells, fibrosarcoma HT1080 cells, and hepatocellular carcinoma HepG2 cells. Compounds 1 – 3 induced cell death was characterized by endoplasmic reticulum (ER) swelling and cytoplasmic vacuolization, typical morphological changes associated with paraptosis. Mechanistic studies revealed that compounds 1 and 3 triggered paraptosis-like cell death through the accumulation of reactive oxygen species (ROS), activation of ER stress, and stimulation of the MAPK signaling pathway. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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