| Autor: |
Xu, Dan, Chen, Yajun, Cao, Xu-Xu, Zheng, Jingjie, Wang, Yao, Ma, Yan-Yan, Zhang, Kun, Zhao, Deng-Gao |
| Zdroj: |
Phytochemistry Letters; Jun2024, Vol. 61, p187-190, 4p |
| Abstrakt: |
A new diarylpropane (1) along with seventeen known compounds (2 – 18), were extracted from the entire plant of Dianella ensifolia. The compounds 1 – 3 were identified as a distinctive group of diarylpropanes. Their structures were determined through comprehensive spectral analysis. An anti-inflammatory activity assay revealed that compound 7 demonstrated significant inhibitory effects on NO generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, with an IC 50 value of 9.93 μg/mL. Further in-depth mechanistic studies indicated that compound 7 suppresses LPS-induced NO production by inhibiting the activation of NF-κB, which subsequently led to a decrease in the expression of nitric oxide synthase enzymes (iNOS). [Display omitted] • A new diarylpropane was isolated from Dianella ensifolia. • Compound 7 showed effective anti-inflammatory activity. • Compound 7 inhibited the activation of NF- κ B. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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