| Autor: |
Banerjee, Roon, Ghanty, Rituparna, Jagtap, Soham, Holla, Vikram, Kamble, Nitish, Yadav, Ravi, Pal, Pramod Kumar, Datta, Indrani |
| Zdroj: |
Stem Cell Research; Jun2024, Vol. 77, pN.PAG-N.PAG, 1p |
| Abstrakt: |
The Parkin (PRKN) gene mutation is prevalent in young-onset Parkinson's disease (PD), typically emerging before age 30, accompanied by early motor symptoms. Induced pluripotent stem cells (iPSCs) were derived from peripheral blood mononuclear cells of a PD patient with an exon 3 deletion in PRKN using Sendai-virus reprogramming. PD diagnosis was confirmed via the Unified Parkinson's Disease Rating Scale (UPDRS). Characterization of the iPSC line ensured self-renewal and pluripotency. This resource serves as a valuable platform for drug screening and elucidating the pathophysiology of this mutation, facilitating advancements in PD research. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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