| Abstrakt: |
Objective: To describe the use of bioreactors for hematopoeitic stem cell and progenitor cell culture and comparing the various bioreactors to know which one is the best. Materials and Method: We conducted a data search on PubMed in December 18, 2021 and January 18, 2022. We used "Bioreactor" AND "Hematopoietic stem cell" OR "progenitor" as keywords. Data collection procedure: search results were filtered and selected so that only articles, which contained data about the type of bioreactor, mechanism of bioreactor, and cell source of HSC and progenitors, were used. Result and Discussion: The search yielded nine articles that were used to compose this narrative review. There are two main bioreactor classification, perfusion and stirred tank bioreactor. There are various models, which can be adapted easily according to research needs, such as microfluidic, hollow fibre, continuous perfusion and micro-cavity array bioreactors. Conclusion: Comparison between those bioreactors showed that perfusion bioreactor is more advantageous and widely used for research purposes that are related to HSCs and progenitors. This fact is due to the possibility of a simpler type and more benefits than stirred types. [ABSTRACT FROM AUTHOR] |
