Development of a Process to a 4‑Arylated 2‑Methylisoquinolin-1(2H)‑one for the Treatment of Solid Tumors: Lessons in Ortho-Bromination, Selective Solubility, Pd Deactivation, and Form Control.

Autor: Primer, David N., Yong, Kelvin, Ramirez, Antonio, Kreilein, Matthew, Ferretti, Antonio C., Ruda, Antonio M., Fleary-Roberts, Nadia, Moseley, Jonathan D., Forsyth, Siân M., Evans, Graham R., Traverse, John F.
Zdroj: Organic Process Research & Development; 5/20/2022, Vol. 26 Issue 5, p1458-1469, 12p
Databáze: Supplemental Index