Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.

Autor: Guanglin Luo, Ling Chen, Kostich, Walter A., Hamman, Brian, Allen, Jason, Easton, Amy, Bourin, Clotilde, Gulianello, Michael, Lippy, Jonathan, Nara, Susheel, Pattipati, Sreenivasulu Naidu, Dandapani, Kumaran, Dokania, Manoj, Vattikundala, Pradeep, Sharma, Vivek, Elavazhagan, Saravanan, Verma, Manoj Kumar, Lal Das, Manish, Wagh, Santosh, Balakrishnan, Anand
Zdroj: Journal of Medicinal Chemistry; 3/24/2022, Vol. 65 Issue 6, p4534-4564, 31p
Databáze: Supplemental Index