| Autor: |
Ricu, G., Barbu, M., Rascu, S., Radavoi, D., Jinga, V. |
| Předmět: |
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| Zdroj: |
Romanian Journal of Urology; 2020, Vol. 19 Issue 4, p33-38, 6p |
| Abstrakt: |
Introduction and Objectives. Results after external beam radiotherapy have significantly improved through dose escalation and the use of androgen deprivation therapy (ADT). The purpose of this study was to assess the long-term urinary, bowel, and sexual functions after image guided radiotherapy (IGRT). Materials and Methods. Our study group included 85 men with localized prostate cancer (clinical classification T1-3 N0 (pN0) M0) treated with external beam radiotherapy guided on intraprostatic fiducial gold markers, between 2012 and 2017. The radiation dose ranged from 74 to 78 Gy (mean dose of 77,9 Gy); 72 men had received ADT for 6 to 36 months. Functional status was assessed at baseline every three months in the first year, and every six months from two to five years. Results. After five years of follow up, 83% of patients presented with no symptoms of late rectal toxicity. Grade 2 gastrointesitanl (GI) toxicity was present in 12 patients (14,11%). Grade 3 proctitis was reported for two patients (2.4%). Comparing the urinary status before radiotherapy and two and five years after completing radiotherapy, 68%, respectively 61% of patients reported improvement of symptoms. One patient developed urethral stricture seven months after completion of radiotherapy. Erectile function defined as the ability to achieve an erection adequate for intromission was present in 62 patients (73%) before treatment. Out of these, 33 (53%) presented with erectile dysfunction 4 years after the treatment. There were no Grade 4 or fatal toxicity encountered. Conclusion. In the modern era, treatment consisting of high-dose radiotherapy delivered with advanced radiotherapy techniques (intensity-modulated radiation therapy and image-guided radiation therapy) which significantly improve tumor control, can contribute to reduction of late toxicity. [ABSTRACT FROM AUTHOR] |
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