Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression.

Autor:	Okoye, Jude O., Ngokere, Anthony A., Onyenekwe, Charles C., Omotuyi, Olaposi, Dada, Deborah I.
Předmět:	HERPES simplex virus EPSTEIN-Barr virus ENZYME-linked immunosorbent assay P53 antioncogene PAPILLOMAVIRUSES MICRORNA VIRUS diseases
Zdroj:	African Journal of Laboratory Medicine; 2021, Vol. 10 Issue 1, p1-10, 10p
Abstrakt:	This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. This study suggests that malignancies associated with viral co-infection could be diagnosed early by monitoring cluster of differentiation 4+ T-cell counts and serum expression of miR-145 and miR-182. [ABSTRACT FROM AUTHOR]
Databáze:	Supplemental Index
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