| Abstrakt: |
Introduction: The presence of cognitive impairment is one of the essential aspects in epileptology. At the same time, neuropathologists involved in the treatment of epilepsy, often underestimates this disorder. Ignoring these disorders in the future can lead to their aggravation, decrease in social adaptation and quality of life, aggravating the disability of patients. Purpose of the Study: To analyze patients with cognitive impairment due to idiopathic epilepsy and epileptic syndrome of alcoholic, cerebrovascular, post-traumatic and neurosurgical postoperative origin, gone through Mini-Mental state examination (MMSE) to assess the cognitive impairment. Materials and Methods: The research has been conducted from April to December 2015 on the basis of State budget institution of the Republic of Crimea "Republican Psychiatric Hospital No. 1". Clinically-anamnestically, clinically psychopathologically, psychometrically (MMSE, FAB scale, Schulte table, clock drawing test). 76 male patients were examined, which, according to the etiological affiliation of the epileptic syndrome. They were divided into 5 groups: Group 1 - Idiopathic epilepsy (22 patients, medium age - 37.3 years); Group 2 - Epileptic syndrome of alcoholic origin (11 patients, average age - 44.5 years); Group 3 - Epileptic syndrome due to a traumatic brain injury (23 patients, average age - 45 years); Group 4 - Epileptic syndrome of neurosurgical postoperative genesis (10 patients, average age - 43 years); Group 5 - Epileptic syndrome due to cerebrovascular pathology (10 patients, average age - 48.2 years). The data obtained were processed by nonparametric statistical methods for small groups (Anova - Kraskela-Walis), Mann-Whitney U-test. Research Results: In patients with epilepsy and epileptic syndromes, the comparative analysis of the cognitive disorders was performed. It was found that the severity of cognitive impairment in patients with epileptic syndrome going to the medical and social expert commission increases in the following order: 1) idiopathic epilepsy (which corresponds to mild cognitive impairment); 2) epileptic syndrome alcoholic origin, as a result of traumatic brain injury and post-operative neurosurgical epileptic syndrome which corresponds to mild cognitive impairment; 3) epileptic syndrome at cerebrovascular pathology which corresponds to mild dementia. Conclusions: 1) It was found that the severity of cognitive disorders depending on the etiology of convulsive syndrome grows in the following order: a) idiopathic epilepsy; b) epileptic syndromes of alcoholic, post-traumatic and neurosurgical postoperative genesis; c) cerebrovascular epileptic syndrome, which can be recommended to pay attention to clinicians in the first place. 2) Cognitive disorders in symptomatic epilepsy are more severe than in idiopathic epilepsy, and are also more associated with frontal dysfunctions. [ABSTRACT FROM AUTHOR] |
