| Autor: |
Susumu TANAKA, Yohei FUJISHITA, Naomasa KAWAGUCHI, Takasuke USUKI, Yuhki YOKOYAMA, Xin WU, Seiji MORI, Hirofumi YAMAMOTO, Mikihiko KOGO |
| Předmět: |
|
| Zdroj: |
Dental Materials Journal; 2021, Vol. 40 Issue 3, p766-771, 6p |
| Abstrakt: |
The present study was designed to evaluate the effects of the osteopontin-derived multifunctional short peptide, SVVYGLR (SV) peptide on the biological properties of skeletal muscle-specific myogenic cells. We employed human-derived satellite cells (HSkMSC) and skeletal muscle myoblasts (HSMM) and performed a series of biochemical experiments. The synthetic SV peptide showed no influence on the proliferation and adhesion properties of HSkMSC and HSMM, while it showed a significant increase in cell motility, including migration activities upon treatment with the SV peptide. In a rat model with volumetric loss of masticatory muscle, immunohistochemical staining of regenerating muscle tissue immediately after injury demonstrated an increase of the number of both MyoD- and myogenin-positive cells in SV peptide-treated group. These results suggest that SV peptide plays a potent role in facilitating skeletal muscle regeneration by promoting the migration, and differentiation of myogenic precursor and progenitor cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
