| Autor: |
Boys, Ian N., Xu, Elaine, Mar, Katrina B., De La Cruz-Rivera, Pamela C., Eitson, Jennifer L., Moon, Benjamin, Schoggins, John W. |
| Zdroj: |
Cell Host & Microbe; Nov2020, Vol. 28 Issue 5, p712-712, 1p |
| Abstrakt: |
Among mammals, bats are particularly rich in zoonotic viruses, including flaviviruses. Certain bat species can be productively yet asymptomatically infected with viruses that cause overt disease in other species. However, little is known about the antiviral effector repertoire in bats relative to other mammals. Here, we report the black flying fox receptor transporter protein 4 (RTP4) as a potent interferon (IFN)-inducible inhibitor of human pathogens in the Flaviviridae family, including Zika, West Nile, and hepatitis C viruses. Mechanistically, RTP4 associates with the flavivirus replicase, binds viral RNA, and suppresses viral genome amplification. Comparative approaches revealed that RTP4 undergoes positive selection, that a flavivirus can mutate to escape RTP4-imposed restriction, and that diverse mammalian RTP4 orthologs exhibit striking patterns of specificity against distinct Flaviviridae members. Our findings reveal an antiviral mechanism that has likely adapted over 100 million years of mammalian evolution to accommodate unique host-virus genetic conflicts. • A screen identifies flying fox RTP4 as an antiviral effector targeting flaviviruses • RTP4 binds viral RNA and suppresses flavivirus genome amplification • Mammalian RTP4 orthologs exhibit distinct antiviral properties • Escape of RTP4-mediated restriction by a flavivirus is ortholog specific Conflicts between viruses and their hosts drive the evolution of antiviral restriction factors. Boys et al. unveil mammalian RTP4 as an antiviral effector that suppresses the replication of distinct flaviviruses in a species-specific manner, thus highlighting an unappreciated host-pathogen molecular arms race spanning 100 million years of mammalian evolution. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
