| Autor: |
Tamy, Tiemi Suehiro, Malaguti, Natália, Damke, Edilson, Nelson, Shozo Uchimura, Gimenes, Fabrícia, Raquel, Pantarotto Souza, da Silva Vânia, Ramos Sela, Marcia, Edilaine Lopes Consolaro |
| Předmět: |
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| Zdroj: |
International Journal of Gynecological Cancer; Feb2019, Vol. 29 Issue 2, p242-249, 8p |
| Abstrakt: |
Objective: To assess the rates of co-infections between human papillomavirus (HPV) and 13 key markers of bacterial vaginosis in cervical samples by multiplex polymerase chain reaction in a population with a high rate of abnormal cytology and a positive HPV test. Methods: The study included a total of 213 women aged 18–72 years screened using Papanicolaou smears for determining cervical abnormalities and for HPV and bacterial vaginosis by single-target and multiplex polymerase chain reaction. Results: A total of 83 (39%) women were negative for intraepithelial lesion or malignancy cytology and 130 (61%) had abnormal cytology. HPV-DNA prevalence was 69.9% and bacterial vaginosis was 72.7 %. Co-infections between bacterial vaginosis with HPV-DNA and high-risk HPV were associated with an increased risk for squamous intraepithelial lesions of low-grade cytology and high-grade squamous intraepithelial lesions plus cervical cancer. The most frequent bacterial vaginosis agent was Gardnerella vaginalis (33.8%), and co-infection with HPV-DNA and high-risk HPV increased the risk for squamous intraepithelial lesions of low grade cytology and high-grade squamous intraepithelial lesions plus cervical cancer. Co-infection between Megasphaera type I and high-risk HPV increased the risk for high-grade squamous intraepithelial lesions plus cervical cancer. Conclusions: Our results reinforce the hypothesis that some bacterial vaginosis agents may play a role as co-factors in HPV-mediated cervical carcinogenesis, at least in some populations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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