| Autor: |
Helli, Sanaz, Damghani, Hossein, Mohajeri, Daryoush, Abbasi, Mehran Mesgari, Attaran, Rana, Zahed, Maryam |
| Zdroj: |
Journal of Dentistry (2345-6485); Sep2016, Vol. 17 Issue 3, p185-192, 8p, 2 Color Photographs, 2 Charts, 1 Graph |
| Abstrakt: |
Statement of the Problem: Oral cancer is among the ten most common cancers worldwide. It affects the life quality of patients in many ways. Purpose: The aim of this study was to compare the effects of two different systemic doses of Viola Odorata syrup on the prevention of 4-Nitroquinoline-1-oxide (4NQO) induced tongue dysplasia in rats. Materials and Method: Forty-eight male Wistar rats were divided into four groups of A, B, C and D. Group A served as the control group. The rats in groups B to D received 30 ppm of 4-NQO in drinking water for 12 weeks. Additionally, the rats in groups B and C received Viola Odorata syrup at doses of 15 and 5 ml/kg, respectively, 3 times a week. Body weights were measured three times a week. At the end, the rats were euthanized and the tongue was removed. Histological evaluations for carcinogenesis were carried out under a light microscope. Results: The mean body weight of the rats in groups B, C, and D were lower than that in group A (p< 0.01). After 12 weeks of treatment, microscopically no histological changes of the tongue base epithelia were observed in the control group. The rats in group B did not show severe dysplastic changes; only mild to moderate histological changes including hyperplasia and hyperkeratosis were evident. These incidences were significantly more apparent in groups C with moderate to severe changes (p< 0.05) and group D with severe dysplastic changes (p< 0.01). Almost all rats in group D had hyperplasia and manifested all of the stages of dysplasia. Conclusion: Viola Odorata extract has dose-dependent inhibitory effects on the development of tongue induced dysplasia. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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