Effect of fluoxetine on induced tooth movement in rats.

Autor: Franzon Frigotto, Giovana Carla, Miranda de Araujo, Cristiano, Guariza Filho, Odilon, Motohiro Tanaka, Orlando, Batista Rodrigues Johann, Aline Cristina, Souza Camargo, Elisa
Zdroj: American Journal of Orthodontics & Dentofacial Orthopedics; Sep2015, Vol. 148 Issue 3, p450-456, 7p
Abstrakt: Introduction Fluoxetine is a widely used antidepressant. Its various effects on bone mineral density are well described. The aim of this study was to evaluate the effect of fluoxetine on induced tooth movement. Methods Seventy-two Wistar rats were divided into 3 groups: M (n = 24; 0.9% saline solution and induced tooth movement), FM (n = 24; fluoxetine, 10 mg/kg, and induced tooth movement), and F (n = 24; fluoxetine, 10 mg/kg only). After 30 days of daily saline solution or fluoxetine administration, an orthodontic appliance (30 cN) was used to displace the first molar mesially in groups M and FM. The animals were killed 3, 7, and 14 days after placement of the orthodontic appliances. The animals in group F did not receive induced tooth movement but were killed at the same times. We evaluated tooth movement rates, collagen neoformation rates by polarization microscopy, numbers of osteoclast by tartrate-resistant acid phosphatase, and trabecular bone modeling by microcomputed tomography of the femur. Results The tooth movement rates were similar in groups M and FM at all studied time points ( P >0.05). The rate of newly formed collagen had a reverse pattern in groups M and FM, but the difference was not statistically significant ( P >0.05). There were significantly more osteoclasts in group FM than in group F on day 3 ( P <0.01). The trabecular spacing was significantly larger in group F compared with group M on day 14 ( P <0.05). Conclusions Fluoxetine did not interfere with induced tooth movement or trabecular bone in rats. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index
Externí odkaz: