| Abstrakt: |
Objective: To evaluate early-pregnancy levels of ADMA (asymmetric dimethylarginine) in recurrent hypertensive pregnancy.: Study design: In this retrospective observational study, blood samples from 35 normotensive women with a previous hypertensive pregnancy were obtained preconceptionally and at 12, 16 and 20 weeks in their next pregnancy. We assessed ADMA, symmetric dimethylarginine (SDMA), l-arginine and l-citrulline. We analyzed differences in longitudinal patterns between normotensive (NT, n = 18) and recurrent hypertensive (HT, n = 17) pregnancies by linear mixed models, with a sub-analysis for preeclampsia (PE, n = 6).: Main outcome measures: ADMA, SDMA, l-arginine and l-citrulline.: Results: Pre-pregnant SDMA and l-citrulline were lower in HT. At 12 weeks, ADMA and ADMA/SDMA ratio correlated inversely with PAPP-A and ?-hCG, respectively. In both groups, ADMA-related compounds changed inconsistently with advancing (mid-trimester) pregnancy, although in HT, l-arginine tended to decrease between 16 and 20 weeks, a decline consistent in PE.: Conclusion: These data support a modest role for ADMA and related metabolites in the pathogenesis of hypertensive pregnancy.: : [ABSTRACT FROM AUTHOR] |
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