| Autor: |
Ravenscroft, J.C., Layton, A.M., Eady, E.A., Murtagh, M.S., Coates, P., Walker, M., Cove, J.H. |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology; May2003, Vol. 148 Issue 5, p1010-1017, 8p |
| Abstrakt: |
Summary Background Staphylococcus aureus has a role in the pathophysiology of atopic eczema. Topical fusidic acid is widely used in its treatment. There is concern that topical use of fusidic acid may be driving the selection and dissemination of fusidic acid-resistant (FusR ) S. aureus . Objectives To test the hypothesis that treatment of atopic eczema for 2 weeks with topical fusidic acid/steroid combination can increase carriage of FusR S. aureus . Methods Forty-six patients with atopic eczema were allocated randomly to one of two treatment groups. Group 1 (28 patients) were treated with topical 2% fusidic acid plus 0·1% betamethasone cream, and group 2 (18 patients) with topical 2% mupirocin and 0·1% betamethasone cream. The clinical response and nasal and skin colonization with S. aureus were recorded before treatment and after 1 and 2 weeks of therapy. Results Baseline samples from the site of worst eczema showed S. aureus (sensitive and resistant) in 76% of patients, and FusR S. aureus in 26%, with no significant difference between treatment groups. After 1 and 2 weeks, both groups showed similar significant clinical improvement. The overall median clinical improvement was paralleled by a reduction in prevalence and population density of S. aureus (sensitive and resistant) at the worst eczema site (P < 0.0001). However, for FusR S. aureus there was no significant change in the prevalence of carriage, or population density in either group compared to baseline. Over 50% of patients carried S. aureus in the nerves and over 20% carried FusR S. aureus . Neither regimen affected either the prevalence or population density of S. aureus or FusR S. aureus in the nerves. Conclusions In this small study there is no evidence to support the hypothesis that short-term treatment of atopic eczema with fusidic acid/steroid combination increases fusidic acid resistant S. aureus during a 2-week period. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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