Serum adiposity-induced biomarkers in obese and lean children with recently diagnosed autoimmune type 1 diabetes.
| Autor: | Redondo, MJ, Rodriguez, LM, Haymond, MW, Hampe, CS, Smith, EO, Balasubramanyam, A, Devaraj, S |
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| Předmět: |
AUTOIMMUNE disease diagnosis
OBESITY ADIPOSE tissues AUTOANTIBODIES BIOMARKERS C-reactive protein CELL physiology DEMOGRAPHY GLUTAMIC acid GLYCOSYLATED hemoglobin PATIENT aftercare INTERFERONS TYPE 1 diabetes INTERLEUKINS LONGITUDINAL method EVALUATION of medical care PEDIATRICS TUMOR necrosis factors LEPTIN BODY mass index DIAGNOSIS |
| Zdroj: | Pediatric Diabetes; Dec2014, Vol. 15 Issue 8, p543-549, 7p, 2 Charts, 2 Graphs |
| Abstrakt: | Background/Objective Obesity increases the risk of cardiovascular disease and diabetic complications in type 1 diabetes. Adipokines, which regulate obesity-induced inflammation, may contribute to this association. We compared serum adipokines and inflammatory cytokines in obese and lean children with new-onset autoimmune type 1 diabetes. Subjects and Methods We prospectively studied 32 lean and 18 obese children (age range: 2-18 yr) with new-onset autoimmune type 1 diabetes and followed them for up to 2 yr. Serum adipokines [leptin, total and high molecular weight (HMW) adiponectin, omentin, resistin, chemerin, visfatin], cytokines [interferon (IFN)-gamma, interleukin (IL)-10, IL-12, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha] and C-reactive protein (CRP) were measured at a median of 7 wk after diagnosis (range: 3-16 wk). Results Lean children were 71.9% non-Hispanic White, 21.9% Hispanic, and 6.3% African-American, compared with 27.8, 55.6, and 16.7%, respectively, for obese children (p = 0.01). Compared with lean children, obese children had significantly higher serum leptin, visfatin, chemerin, TNF-alpha and CRP, and lower total adiponectin and omentin after adjustment for race/ethnicity and Tanner stage. African-American race was independently associated with higher leptin among youth ≥10 yr (p = 0.007). Leptin levels at onset positively correlated with hemoglobin A1c after 1-2 yr (p = 0.0001) independently of body mass index, race/ethnicity, and diabetes duration. Higher TNF-alpha was associated with obesity and female gender, after adjustment for race/ethnicity (p = 0.0003). Conclusion Obese children with new-onset autoimmune type 1 diabetes have a proinflammatory profile of circulating adipokines and cytokines that may contribute to the development of cardiovascular disease and diabetic complications. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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