| Autor: |
Derangère, V, Chevriaux, A, Courtaut, F, Bruchard, M, Berger, H, Chalmin, F, Causse, S Z, Limagne, E, Végran, F, Ladoire, S, Simon, B, Boireau, W, Hichami, A, Apetoh, L, Mignot, G, Ghiringhelli, F, Rébé, C |
| Předmět: |
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| Zdroj: |
Cell Death & Differentiation; Dec2014, Vol. 21 Issue 12, p1914-1924, 11p, 1 Diagram, 7 Graphs |
| Abstrakt: |
Liver X receptors (LXRs) have been proposed to have some anticancer properties, through molecular mechanisms that remain elusive. Here we report for the first time that LXR ligands induce caspase-1-dependent cell death of colon cancer cells. Caspase-1 activation requires Nod-like-receptor pyrin domain containing 3 (NLRP3) inflammasome and ATP-mediated P2 × 7 receptor activation. Surprisingly, LXRβ is mainly located in the cytoplasm and has a non-genomic role by interacting with pannexin 1 leading to ATP secretion. Finally, LXR ligands have an antitumoral effect in a mouse colon cancer model, dependent on the presence of LXRβ, pannexin 1, NLRP3 and caspase-1 within the tumor cells. Our results demonstrate that LXRβ, through pannexin 1 interaction, can specifically induce caspase-1-dependent colon cancer cell death by pyroptosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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