Polymorphism of SMAD7 gene (rs2337104) and risk of colorectal cancer in an Iranian population: a case-control study.
| Autor: | Akbari, Zahra, Safari-Alighiarloo, Nahid, Taleghani, Mohammad Yaghoob, Mirfakhar, Farzaneh Sadat, Aghdaei, Hamid Asadzadeh, Vahedi, Mohsen, Shemirani, Atena Irani, Nazemalhosseini-Mojarad, Ehsan, Zali, Mohammad Reza |
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| Předmět: |
LIVER disease diagnosis
SMOKING ACADEMIC medical centers CANCER patients CHI-squared test CONFIDENCE intervals COLON tumors REPORTING of diseases GASTROENTEROLOGY GENES GENETIC polymorphisms GENETICS GROWTH factors MEDICAL ethics NOSOLOGY POPULATION T-test (Statistics) RECTUM tumors TUMOR classification DATA analysis CONTROL groups CASE-control method DATA analysis software ODDS ratio GENOTYPES DIAGNOSIS TUMOR risk factors CANCER risk factors |
| Zdroj: | Gastroenterology & Hepatology from Bed to Bench; Autumn2014, Vol. 7 Issue 4, p198-205, 8p |
| Abstrakt: | Aim: The purpose of this study was to evaluate the influence of intronic polymorphism of the SMAD7 (Mothers Against Decantaplegic Homolog 7) gene (rs2337104) on the risk of colorectal cancer (CRC) and clinicopathological features in an Iranian population. Background: SMAD7 has been identified as an antagonist of transforming growth factor beta (TGF-b)-mediating fibrosis, carcinogenesis, and inflammation. Regarding to the recent genome-wide scan, a risk locus for colorectal cancer at 18q21 has been found, which maps to the SMAD7 gene. Patients and methods: This case-control study was performed on 109 CRC patients and 109 healthy controls recruited in Taleghani Hospital. The genotyping of all samples were done by TaqMan assay via an ABI 7500 Real Time PCR System (Applied Biosystems) with DNA from peripheral blood. The association of this polymorphism with the risk of CRC and clinicopathological features was investigated. Results: Our results indicated that there were no significant association between genotypic and allelic frequencies of SMAD7 polymorphism (rs2337104) and CRC risk in our population. Although the T allele is the most frequent one in this population and its frequency was 86.7% in patients compared with 91.7% in controls (OR=1.705, 95% CI= 0.916-3.172). Also, the SMAD7 genotypes were not associated with any clinicopathological characteristics in CRC patients (P>0.05). Conclusion: For the first time, this study results revealed that this SMAD7 polymorphism couldn't be a potential risk factor for CRC or a prognostic biomarker for prediction of clinicopathological features in an Iranian population. A largescale case-control study is needed to validate our results. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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