| Autor: |
Piven, O., Palchevska, O., Lukash, L. |
| Zdroj: |
Cytology & Genetics; Sep2014, Vol. 48 Issue 5, p333-343, 11p |
| Abstrakt: |
Wnt/β-catenin signaling has a great and diverse influence on the formation, development, and vital activity of a great number of vertebrate tissues, including heart tissue. The role of Wnt/β-catenin signaling and β-catenin itself in the processes of cardiogenesis and adult myocardium functioning is not fully elucidated to date. The current review regards the attempt to generalize contemporary literature data on participation of this signaling pathway in embryogenesis and postnatal heart development, as well as in adult myocardium functioning in normal conditions and during stress adaptation, and aging, resulting in hypertrophy and heart remodeling. Based on the experimental articles and reviews, we can assume that Wnt/β-catenin signaling pathway is involved not only in controlling the cardiogenesis but also in processes of adaptation and remodeling of the adult organ. This control can be characterized as complicated and multistep and β-catenin appears to be a prospective candidate as a target for development of new approaches to adult myocardium pathologies therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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