| Autor: |
Klyubin, Igor, Nicoll, Andrew J., Khalili-Shirazi, Azadeh, Farmer, Michael, Canning, Stephanie, Mably, Alexandra, Linehan, Jacqueline, Brown, Alexander, Wakeling, Madeleine, Brandner, Sebastian, Walsh, Dominic M., Rowan, Michael J., Collinge, John |
| Předmět: |
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| Zdroj: |
Journal of Neuroscience; 4/30/2014, Vol. 34 Issue 18, p6140-6145, 6p |
| Abstrakt: |
Alzheimer's disease (AD) is associated with pathological assembly states of amyloid-β protein (Aβ). Aβ-related synaptotoxicity can be blocked by anti-prion protein (PrP) antibodies, potentially allowing therapeutic targeting of this aspect of AD neuropathogenesis. Here, we show that intravascular administration of a high-affinity humanized anti-PrP antibody to rats can prevent the plasticity-disrupting effects induced by exposure to solubleADbrain extract. These results provide an in vivo proof of principle for such a therapeutic strategy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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