| Autor: |
Garg, Preeti, Singh, Amandeep, Walia, Rani, Harbir Kaur Rao, Prithpal Singh Matreja, Amarjit Kaur Gill, Khanna, P. M. L. |
| Předmět: |
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| Zdroj: |
Middle East Journal of Internal Medicine; Jan2014, Vol. 7 Issue 1, p26-31, 6p |
| Abstrakt: |
Background and Objectives: Uncomplicated lower UTI accounts for around 150 million cases worldwide, every year. Antibiotics commonly used for the treatment of uncomplicated lower UTI include fluoroquinolones, trimethoprim-sulphamethoxazole, nitrofurantoin, cephalosporins, and amoxicillin. No comparative study between levofloxacin and cefuroxime axetil in patients with uncomplicated lower UTI could be searched. So, this randomized study was designed to compare the efficacy and tolerability of levofloxacin 500 mg once daily with cefuroxime axetil 250 mg twice daily in the treatment of uncomplicated lower UTI in adult Indian patients. Methods: This prospective, parallel group comparative study was conducted in 100 patients with uncomplicated lower UTI. Patients were assessed for clinical and bacteriological success over the study period. Results: 89 patients of the total of 100 patients enrolled in the study completed the study. E.coli was the most common organism isolated in both the groups. Patients in levofloxacin group showed improvement in clinical symptoms by 95.35 percent, as compared to 89.13 percent in the cefuroxime group. However, the intergroup difference was not statistically significant (p>0.05). Levofloxacin group showed decrease in bacteriological scoring by 95.35 percent, and cefuroxime group showed decrease by 86.96 percent. The difference in bacteriological scoring between the two treatment groups was not significant (p>0.05). Conclusion: The results of our study show that cefuroxime axetil in a dose of 250 mg twice daily and levofloxacin 500 mg once daily for three days, are equally efficacious in treating patients with uncomplicated lower UTI. The comparative clinical and bacteriological successes between the two groups were statistically not significant, and both drugs were well-tolerated by the patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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