| Autor: |
Cangiano, Carlo, Ceci, Fabrizio, Cascino, Antonia, Del Ben, Maria, Laviano, Alessandro, Muscaritoli, Maurizio, Antonucci, Fabiola, Rossi-Fanelli, Filippo |
| Předmět: |
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| Zdroj: |
American Journal of Clinical Nutrition; Nov1992, Vol. 56 Issue 5, p863-867, 5p |
| Abstrakt: |
Previous observations have shown that oral administration of 5-hydroxytryptophan (5-HTP) without dietary prescriptions causes anorexia, decreased food intake, and weight loss in obese subjects. To confirm these data over a longer period of observation and to verify whether adherence to dietary restriction could be improved by 5-HTP, 20 obese patients were randomly assigned to receive either 5-HTP (900 mg/d) or a placebo. The study was double-blinded and was for two consecutive 6-wk periods. No diet was prescribed during the first period, a 5040-kJ/d diet was recommended for the second. Significant weight loss was observed in 5-HTP-treated patients during both periods. A reduction in carbohydrate intake and a consistent presence of early satiety were also found. These findings together with the good tolerance observed suggest that 5-HTP may be safely used to treat obesity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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