Hypoxia, angiotensin-II, and norepinephrine mediated apoptosis is stimulus specific in canine failed cardiomyocytes: a role for p38 MAPK, Fas-L and cyclin D1
Autor: | Sharov, Victor G., Todor, Anastassia, Suzuki, George, Morita, Hideaki, Tanhehco, Elaine J., Sabbah, Hani N. |
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Předmět: |
APOPTOSIS
CARDIOMYOPATHIES HEART failure HEART cells CELL metabolism ANIMAL experimentation BIOLOGICAL models CELLS COMPARATIVE studies DOGS LONGITUDINAL method RESEARCH methodology MEDICAL cooperation NORADRENALINE PROTEINS RESEARCH RESEARCH funding TRANSFERASES ANGIOTENSIN II EVALUATION research DISEASE incidence MEMBRANE glycoproteins PHARMACODYNAMICS |
Zdroj: | European Journal of Heart Failure; Mar2003, Vol. 5 Issue 2, p121-129, 9p |
Abstrakt: | Background: Apoptosis may contribute to the myocardial dysfunction associated with heart failure (HF). Activation of the p38 MAPK cascade can induce apoptosis in non-cardiac cells through increased expression of Fas-L, or through decreased expression of cyclin D |
Databáze: | Complementary Index |
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