| Autor: |
Shcherbina, I. A., Lipets, E. N., Abaeva, A. A., Balandina, A. N., Ataullakhanov, F. I. |
| Zdroj: |
Biochemistry (Biokhimiya). Supplemental Series B, Biomedical Chemistry; Oct2013, Vol. 7 Issue 4, p311-318, 8p |
| Abstrakt: |
Using thrombodynamics, a novel in vitro hemostasis assay, which imitates the process of hemostatic clot growth in vivo, we have investigated the process of spatial fibrin clot formation in non-steered platelet-free plasma of healthy volunteers at the temperatures ranged from 20 to 43°C. The temperature dependence of extrinsic and intrinsic tenase activities, which determine values of the initial and stationary clot growth rates, respectively, has been determined. Lowering the temperature from 37 to 24°C mainly extended the initiation phase of clot growth, while the stationary rate of clot growth remained basically unchanged. During the temperature decrease up to 24°C (acute hypothermia) none of the thrombodynamics parameters demonstrated any dramatic change of the plasma coagulation system. Thus, the thrombodynamics assay provided additional arguments supporting the viewpoint, that the temperature lowering itself insignificantly influences the state of the plasma hemostasis system. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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