| Autor: |
Mann, S, Craig, MW, Balasubramanian, V, Raftery, EB |
| Zdroj: |
British Journal of Clinical Pharmacology; 1981, Vol. 12 Issue 2, p223-228, 6p |
| Abstrakt: |
1 The ambulant intra-arterial blood pressure of eighteen hypertensive subjects was monitored before and again after 3 months treatment with thrice daily sotalol (six patients), twice daily pindolol (six patients) and once daily pindolol (six patients). 2 Three patients in the sotalol group underwent a third study having changed to a once daily regimen; similarly six patients in the pindolol groups were restudied having crossed over to the alternative pindolol dosing regimen, total daily dosage being maintained in all cases. 3 Comparison of 24 h blood pressure curves before and after treatment showed effective daytime reduction but less consistent effects at night. 4 In the crossover experiments once daily and multiple daily dosing regimens produced identical patterns of reduction over 24 h in both blood pressure and heart rate. 5 It is inferred that in the treatment of hypertension, once daily dosing with standard preparations of beta- adrenoceptor blocking agents is probable adequate. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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