The Pharmacological effects of novel 5-fluoro- N-(9,10-dihydro-9,10-dioxoanthracen-8-yl)-1 H-indole-2-carboxamide derivatives on plasma lipid profile of Triton-WR-1339-induced Wistar rats.

Autor: Shattat, Ghassan, Al-Qirim, Tariq, Sheikha, Ghassan Abu, Al-Hiari, Yusuf, Sweidan, Kamal, Al-Qirim, Rania, Hikmat, Suhair, Hamadneh, Lama, Al-kouz, Sameer
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Zdroj: Journal of Enzyme Inhibition & Medicinal Chemistry; Aug2013, Vol. 28 Issue 4, p863-869, 7p
Abstrakt: A novel series of 5-fluoro- N-(9,10-dihydro-9,10-dioxoanthracen-8-yl)-1 H-indole-2-carboxamides ( 3c- 3g) were synthesized. The present study was undertaken to investigate the possible antihyperlipidemic effect of these novel compounds on hyperlipidemic rats. Hyperlipidemia was induced by a single intraperitoneal injection of Triton WR-1339 (300 mg/kg). The tested animals were divided into normal control (NCG), hyperlipidemic control (HCG), compounds 3c-, 3d-, 3e-, 3f-, 3g- and bezafibrate (BF)-treated groups. At a dose of 15 mg/kg, compounds 3c- 3g and BF (100 mg/kg) significantly ( p < 0.0001) reduced elevated plasma triglycerides levels after 12 and 24 h compared to the hyperlipidemic control group. However, only compounds 3e and 3g obviously showed a significant ( p < 0.0001) reduction in plasma total cholesterol levels after 12 and 24 h. Moreover, high-density lipoprotein cholesterol levels were significantly increased in all treated groups. The current study demonstrates that 5-fluoro- N-(9,10-dihydro-9,10-dioxoanthracen-8-yl)-1 H-indole-2-carboxamides ( 3c- 3g) have a definite antihyperlipidemic potential and these beneficial activities may contribute to their cardioprotective and antiatherosclerotic role. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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