SYNTHESIS AND ANTIVIRAL ACTIVITY OF D- AND L-2′-AZIDO-2′,3′-DIDEOXY-4′-THIOPYRIMIDINE AND PURINE NUCLEOSIDES.

Autor:	Jeong, LakShin, Kim, YunHa, Kim, HeaOk, Yoo, SuJeong, Park, YongHee, Yeon, SookHee, Chun, MoonWoo, Kim, Hee-Doo
Předmět:	NUCLEOSIDES BIOSYNTHESIS ANTIVIRAL agents HIV HERPES simplex virus
Zdroj:	Nucleosides, Nucleotides & Nucleic Acids; Apr2001, Vol. 20 Issue 4-7, p665-668, 4p
Abstrakt:	Novel D- and L-2′-azido-2′,3′-dideoxy-4′-thionucleosides were synthesized starting from L- and D-xylose via D- and L-4-thioarabitol derivative as key intermediates and evaluated for antiviral activity, respectively. When the final nucleosides were tested against HIV-1, HSV-1, HSV-2, and HCMV, they were found to be only active against HCMV without cytotoxicity up to 100 μg/ml. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.