| Autor: |
Dajani, Asad I., Abu Hammour, Adnan M., Ding H. Yang, Chung, Peter C., Nounou, Mohammed A., Kaitao Y. Yuan, Zakaria, Mohammed A., Hanping S. Schi |
| Předmět: |
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| Zdroj: |
Saudi Journal of Gastroenterology; May/Jun2013, Vol. 19 Issue 3, p113-120, 8p, 5 Charts, 1 Graph |
| Abstrakt: |
Background: The standard triple therapy for the eradication of Helicobacter pylori consists of a combination of a proton pump inhibitor at a standard dose together with two antibiotics (amoxicillin 1000 mg plus either clarithromycin 500 mg or metronidazole 400 mg) all given twice daily for a period of 7.14 days. Recent reports have shown a dramatic decline in the rate of H. pylori eradication utilizing standard triple therapy from 95% down to 70.80%. Aims: Our study was designed to evaluate the effect of adding a probiotic as an adjuvant to common regimens used for H. pylori eradication. Materials and Methods: An open label randomized observational clinical study was designed to test three different regimens of H. pylori eradication treatment: Standard triple therapy with a concomitant probiotic added at the same time (n = 100), starting the probiotic for 2 weeks before initiating standard triple therapy along with the probiotic (n = 95), and the third regimen consists of the probiotic given concomitantly to sequential treatment (n = 76). The three arms were compared to a control group of patients treated with the traditional standard triple therapy (n = 106). Results: The eradication rate for the traditional standard therapy was 68.9%, and adding the probiotic gBifidus infantish to triple therapy, led to a successful rate of eradication of 83% (P < 0.001). Pre.treatment with 2 weeks of B. infantis before adding it to standard triple therapy increased the success rate of eradication to 90.5%. Similar improvement in eradication rate was noted when B. infantis was added as an adjuvant to the sequential therapy leading to an eradication rate of 90.8%. Conclusion: Adding B. infantis as an adjuvant to several therapeutic regimens commonly used for the eradication of H. pylori infection significantly improves the cure rates. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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