| Autor: |
Span, Paul N, Manders, Peggy, Heuvel, Joop J, Thomas, Chris MG, Bosch, Remko R, Beex, Louk VAM, Sweep, CGJ (Fred) |
| Předmět: |
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| Zdroj: |
Oncogene; 12/5/2002, Vol. 21 Issue 55, p8506, 4p |
| Abstrakt: |
The transcription factor Ets-1 regulates the expression of several angiogenic and extracellular matrix remodeling factors, and might be implicated in disease progression of breast cancer. In the present study, the prognostic value of Ets-1 expression was assessed by quantitative real-time fluorescence RT–PCR in 123 sporadic primary breast cancer samples of patients with a median follow-up time of 62 months. Ets-1 expression levels correlated significantly with VEGF and PAI-1 in the same tissue. In univariate (P=0.0011) and multivariate (P=0.005) analyses, Ets-1 expression showed significant prognostic value for relapse-free survival. Ets-1 is a strong, independent predictor of poor prognosis in breast cancer. This seems – at least in part – to be attributable to its role in transcriptional regulation of factors involved in angiogenesis (VEGF), and extracellular matrix remodeling (PAI-1).Oncogene (2002) 21, 8506–8509. doi:10.1038/sj.onc. 1206040 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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