Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways.

Autor: Wenle Xia, Mullin, Robert J., Keith, Barry R., Lei-Hua Liu, Hong Ma, Rusnak, David W., Owens, Gary, Alligood, Krystal J., Spector, Neil L.
Předmět:
Zdroj: Oncogene; 9/12/2002, Vol. 21 Issue 41, p6255, 9p, 6 Black and White Photographs, 1 Graph
Abstrakt: Presents a study which examined the anti-tumor activity of the GW572016 molecule. Inhibition of epidermal growth factor receptor erbB2 tyrosine kinases; Inhibition of the activation of Erk1/2 and AKT, downstream effectors of proliferation and cell survival; Materials and methods; Results and discussion.
Databáze: Complementary Index