| Autor: |
Poulin, Eric, Lebel, Réjean, Croteau, EtiENne, Blanchette, Marie, Tremblay, Luc, Lecomte, Roger, BENtourkia, M'hamed, Lepage, Martin |
| Zdroj: |
Magnetic Resonance in Medicine; Mar2013, Vol. 69 Issue 3, p781-792, 12p |
| Abstrakt: |
Reaching the full potential of magnetic resonance imaging (MRI)-positron emission tomography (PET) dual modality systems requires new methodologies in quantitative image analyses. In this study, methods are proposed to convert an arterial input function (AIF) derived from gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) in MRI, into a 18F-fluorodeoxyglucose (18F-FDG) AIF in PET, and vice versa. The AIFs from both modalities were obtained from manual blood sampling in a F98-Fisher glioblastoma rat model. They were well fitted by a convolution of a rectangular function with a biexponential clearance function. The parameters of the biexponential AIF model were found statistically different between MRI and PET. Pharmacokinetic MRI parameters such as the volume transfer constant ( Ktrans), the extravascular-extracellular volume fraction (νe), and the blood volume fraction (νp) calculated with the Gd-DTPA AIF and the Gd-DTPA AIF converted from 18F-FDG AIF normalized with or without blood sample were not statistically different. Similarly, the tumor metabolic rates of glucose (TMRGlc) calculated with 18F-FDG AIF and with 18F-FDG AIF obtained from Gd-DTPA AIF were also found not statistically different. In conclusion, only one accurate AIF would be needed for dual MRI-PET pharmacokinetic modeling in small animal models. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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