Absorption of orally administered 65Zn by normal human subjects.

Autor: Aamodt, Roger L., Rumble, Warren F., Johnston, Gerald S., Markley, Elizabeth J., Henkin, Robert I.
Předmět:
Zdroj: American Journal of Clinical Nutrition; Dec1981, Vol. 34 Issue 12, p2648-2652, 5p, 1 Chart, 3 Graphs
Abstrakt: Despite studies by several investigators of human gastrointestinal 65Zn absorption, implications of these data for evaluation of functional zinc status are unclear because limited numbers of normal subjects have been studied. To evaluate zinc absorption in normal humans, 75 subjects (31 women, 44 men, ages 18 to 84 yr) were given 10 μCi carrier-free 65Zn orally after an overnight fast. Absorption calculated from total body retention measured 7, 14, and 21 days after administration of tracer was 65 ± 11% (mean ± 1 SD), range 40 to 86%. Comparison of these results with those for patients with a variety of diseases indicate that patients exhibit a wider range of absorption and, in four of six studies patients exhibit decreased mean zinc absorption. These results of gastrointestinal zinc absorption in a large number of normal humans offer a basis for a clearer comparison with data from patients who exhibit abnormalities of zinc absorption. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index