Dynamics of Pneumocystis carinii Air Shedding During Experimental Pneumocystosis.

Autor: Choukri, Firas, Aliouat, El Moukhtar, Menotti, Jean, Totet, Anne, Gantois, Nausicaa, Garin, Yves J. F., Bergeron, Vance, Dei-cas, Eduardo, Derouin, Francis
Předmět:
Zdroj: Journal of Infectious Diseases; May2011, Vol. 203 Issue 9, p1333-1336, 4p
Abstrakt: To better understand the diffusion of Pneumocystis in the environment, airborne shedding of Pneumocystis carinii in the surrounding air of experimentally infected rats was quantified by means of a real-time polymerase chain reaction assay, in parallel with the kinetics of P. carinii loads in their lungs. P. carinii DNA was detected in the air 1 week after infection and increased until 4–5 weeks after infection before stabilizing. A significant correlation was shown between lung burdens and the corresponding airborne levels, suggesting the possibility of estimating the fungal lung involvement through quantification of Pneumocystis in the exhaled air. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index