| Autor: |
Longhi, Silvia, Pasquino, Bruno, Calcagno, Annalisa, Bertelli, Enrica, Olivieri, Irene, Di Iorgi, Natascia, Radetti, Giorgio |
| Předmět: |
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| Zdroj: |
Clinical Endocrinology; Jan2013, Vol. 78 Issue 1, p79-85, 7p, 4 Charts, 2 Graphs |
| Abstrakt: |
Objective It is still not known whether fat mass excess could exert a positive effect on bone. The aim of our study was to evaluate bone strength and quality in a group of overweight and obese children and adolescents by assessing bone geometry at metacarpal bones and ultrasound at phalangeal level. Design and patients This is a cross sectional observational study performed in 123 subjects, aged 11·2 ± 2·9 years. Measurements Digitalized X-rays were evaluated at the level of the 2nd metacarpal bone for the determination of the outer ( D) and inner ( d) diameter, cortical area ( CA), medullary endocortical area ( EA), metacarpal index ( MI) and bone strength (Bending Breaking Resistance Index; BBRI). A total of 98 subjects underwent amplitude dependent speed of sound (Ad- SOS) and bone transmission time ( BTT) assessment by phalangeal ultrasonography. Results SDs for each measured parameter were as follows: Males: D = −0·71 ± 0·95, d = −0·29 ± 0·86, CA = −0·69 ± 0·69, EA = −0·32 ± 0·79, Ad- SOS = −1·14 ± 0·91, BTT = −1·17 ± 1·11 and BBRI (417 ± 151 vs 495 ± 174 mm3) were all significantly lower than in controls ( P < 0·05). Females: D = −1·03 ± 1·06, d = −0·38 ± 0·92, CA = −0·91 ± 0·72, EA = −0·46 ± 0·79, Ad- SOS = −1·08 ± 1·11, BTT = −0·97 ± 1·07 and BBRI (342 ± 117 vs 649 ± 318 mm3) were all significantly lower than in controls ( P < 0·05). Conclusions Obese children show an unfavourable bone geometry and a bone of low quality and reduced strength compared to controls at a nonweight bearing skeletal site. This finding seems to support a detrimental effect of fat mass on bone and explain the frequent occurrence of wrist fractures in this group of children. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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