| Autor: |
Susan Clardy-James, Jaime Bernstein, Deborah Kerwood, Robert Doyle |
| Předmět: |
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| Zdroj: |
Synlett; Oct2012, Vol. 23 Issue 16, p2363-2366, 4p |
| Abstrakt: |
Reaction of vitamin B12 (B12) with excess 2-iodoxybenzoic acid and 2-hydroxypyridine leads to selective oxidation of the 5′-hydroxyl group of the ribose tail of B12 in a 30% isolated yield. The acid derivative was purified in one step by HPLC chromatography and characterized by MALDI-TOF mass spectrometry, 1H NMR and 2D (HSQC and HMBC) NMR. The new carboxylic acid derivative is perfectly suited to make stable amide-based B12 bioconjugates. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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