| Autor: |
Pruett, Jack K., Woods, Eugene F., Daniell, Herman B. |
| Zdroj: |
Cardiovascular Research; Oct1971, Vol. 5 Issue 4, p436-439, 4p |
| Abstrakt: |
Glass microelectrodes were used to study the effect of glucagon on phase 4 of Purkinje fibre action potentials. Glucagon enhanced automaticity of canine Purkinje fibres in false tendons as evidenced by increases in spontaneous rate and increases in the slope of phase 4 depolarization. Mean control rate of spontaneously beating fibres was 46·2 ± SE 5·06/min. After addition of glucagon to the bath, rate increased to a mean of 62·2 ± SE 5·29/min, 34% above control value. Rates after treatment with glucagon were significantly different from control (P < 0.001) and compared favourably, on a percentage basis, with increased rates reported in isolated cat atria, intact dogs, and dogs with complete heart block after glucagon administration. This study demonstrates that glucagon influences automaticity of fibres below the A-V node. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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