| Autor: |
de Mey, Christian, Hinder, Markus |
| Zdroj: |
Drug Discovery & Evaluation: Methods in Clinical Pharmacology; 2011, p387-421, 35p |
| Abstrakt: |
Cardiovascular function reflects the overall ability of the two cardiac pumps and their circulation to secure tissular functionality by providing an adjusted supply of oxygen and nutrients while eliminating biological waste products. Failure of this ability causes severe damage and, if protracted and/or extensive, may be lethal. Leading causes of death are cardiovascular (life-threatening dysrhythmia, coronary and cerebrovascular atherosclerotic vasculopathies, heart [pump] failure, etc.) and related morbidity is highly incapacitating with important negative socio-economic implications. It is therefore self-evident that cardiovascular morbidity and mortality and its precursor conditions (atherosclerosis) or risk factors (hypertension) are important target indications for drug development. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
