Transdermal Absorption of L-Dopa from a New System Composed of two Separate Layers of L-Dopa and Hydrogel in Rats.

Autor: Iwase, Hiroaki, Sudo, Jun-ichi, Terui, Jun, Kakuno, Katsuhiko, Watanabe, Takiko, Takayama, Kozo, Nagai, Tsuneji
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Zdroj: Drug Development & Industrial Pharmacy; Jul2000, Vol. 26 Issue 7, p755-759, 5p
Abstrakt: To maintain the stability of L-dopa in hydrogel, a new system composed of two separate layers of L-dopa and hydrogel was developed. L-Dopa sheets were made by immersing L-dopa solution into wiper sheets and by lyophilizing them. Examination for stability of L-dopa in the L-dopa sheet revealed that its stability was maintained for at least 12 weeks, providing the sheet was kept at room temperature in a dark box. In a cutaneous absorption study of L-dopa in rats, an L-dopa sheet was attached to the shaved abdominal skin. A hydrogel composed of cutaneous absorption enhancers, water and ethanol, was spread on vinyl tape (hydrogel sheet), and this sheet was placed over the L-dopa sheet. L-Dopa that was administered transdermally effectively penetrated through the skin: The plasma level of L-dopa peaked at 30 min and remained high between 60 and 180 min after the cutaneous application. Our system, composed of two separated layers of L-dopa and hydrogel, enabled the stability of L-dopa to be maintained without losing transdermal absorption of L-dopa. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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