| Autor: |
Gautam, S., Gautam, Savita, Deodhar, S. |
| Zdroj: |
Journal of Cancer Research & Clinical Oncology; 1981, Vol. 101 Issue 3, p265-274, 10p |
| Abstrakt: |
The responsiveness of spleen cells from C57BL/6J mice to various immunogenic stimuli was examined during the progressive growth of a poorly immunogenic fibrosarcoma T241. A strong correlation was observed between the progressive tumor growth and the depression of response to Concanavalin A, lipopolysaccharide, sheep red blood cells, and alloantigens in mixed lymphocyte reaction and cell-mediated lympholysis (CML). The maximum depression of these immune responses occurred when the animals had grown tumors for 3-4 weeks. Furthermore, serum from these animals collected 20 days after tumor transplantation was highly immunosuppressive. The possible mechanisms of tumor-induced immunosuppression have been discussed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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