PERG and spectral sensitivity in ocular hypertensive and chronic open-angle glaucoma patients.

Autor: Bielik, Magda, Zwas, Fred, Shin, Dong, Tsai, Clark
Zdroj: Graefe's Archive of Clinical & Experimental Ophthalmology; 1991, Vol. 229 Issue 5, p401-405, 5p
Abstrakt: Pattern electroretrinography (PERG) was performed in 33 patients with chronic open-angle glaucoma (COAG), 18 ocular hypertensive (OH) patients, and 24 normal subjects. COAG patients exhibited significantly lower PERG amplitudes than did normal subjects ( P = 0.025; P < 0.0001). The OH patients fell into two distinct groups: those with normal PERG scores and those with lower than normal scores. OH patients with PERG scores significantly lower than control values demonstrated significantly larger cup-to-disc ratios ( P=0.002) and higher initial intraocular pressures (IOPs) than did OH patients with normal PERG scores ( P=0.021). In the 11 OH patients in whom spectral sensitivity measurement was available, statistically significant correlations were found between the blue-cone sensitivity loss and the PERG amplitude ( r)=0.772, P=0.0053 and r=0699, P=0.0167, respectively. our results demonstrate reduced PERG amplitude in high-risk OH patients and further illustrate the correlation between PERG amplitude and blue-cone spectral sensitivity in OH subjects. Confirmation of the roles of PERG and spectral sensitivity in the detection of early glaucoma requires longitudinal study. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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